Elastin-lipid Interaction in Arterial Wall
نویسندگان
چکیده
منابع مشابه
Increase in Circumferential Stress in Arterial Wall Due to Loss of Function of Elastin
Introduction Increase of mechanical stress in the arterial wall leads to an altered arterial function and structural degeneration. The study of circumferential stress profile across the arterial wall, and change of this profile by functional loss of components can enhance understanding of pathological events in arterial degeneration and disease [Avolio et al. 1998, Loree et al . 1992, Spina et ...
متن کاملThe interaction of serum and arterial lipoproteins with elastin of the arterial intima and its role in the lipid accumulation in atherosclerotic plaques.
Arterial elastin appears to be a proteinlipid complex with the lipid component being bound to elastin peptide groups. In atherosclerotic lesions the lipid content of elastin increases progressively with increasing severity of atherosclerosis. The increases in the lipid content of plaque elastin are mainly due to large increases in cholesterol with about 80% of the cholesterol being cholesterol ...
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Introduction: Arterial stiffness is an important predictor of cardiovascular risk. Several indices have been introduced to estimate the arterial stiffness based on the changes in the brachial blood pressure. Since the substitution of the blood pressure changes in the central arteries such as carotid with the blood pressure changes in the brachial results in error in the blood...
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BACKGROUND The computation of arterial wall deformation and stresses under physiologic conditions requires a coupled compliant arterial wall-blood flow interaction model. The in-vivo arterial wall motion is constrained by tethering from the surrounding tissues. This tethering, together with the average in-vivo pressure, results in wall pre-stress. For an accurate simulation of the physiologic c...
متن کاملNovel arterial pathology in mice and humans hemizygous for elastin.
Obstructive vascular disease is an important health problem in the industrialized world. Through a series of molecular genetic studies, we demonstrated that loss-of-function mutations in one elastin allele cause an inherited obstructive arterial disease, supravalvular aortic stenosis (SVAS). To define the mechanism of elastin's effect, we generated mice hemizygous for the elastin gene (ELN +/-)...
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ژورنال
عنوان ژورنال: The Journal of Japan Atherosclerosis Society
سال: 1982
ISSN: 0386-2682,2185-8284
DOI: 10.5551/jat1973.10.2_305